SGTI - Posinol

Depression is a mood disorder that causes one to feel sad or hopeless for an extended period of time. According to the Depression and Bipolar Support Alliance, depression is the most common serious brain disease in the United States, affecting more than 23 million adults each year. Despite advances in the pharmacotherapy of depression, only one third of patients respond favorably to antidepressant drugs. Because of the poor outcomes of treatment with antidepressant medication, patients are increasingly using complementary and alternative medicine.

One such alternative is Posinol™. It is made with an extract from the leaves of Apocynum venetum L., a wild plant grown in Asia. Posinol™ contains no less than 4% of the flavonoid glycosides-isoquercitrin and hyperoside. Hyperoside is known to be most efficacious in mental relaxation and reducing blood pressure. It works with the brain's naturally-occurring chemicals called neurotransmitters, including norepinephrine and dopamine. Posinol™ differs from St. John's wort in that it does not contain hyperforin, an active compound that interacts with the metabolism of certain pharmaceuticals.

PosinolT has several case reports indicating that doses of 50 mg/day could help in reducing symptoms of mild to moderate depression.

PosinolT shortened the immobility time in an animal model for antidepressant activity at a dose of 15 mg/kg, indicating possible antidepressant activity. This effect was comparable to that of the antidepressant drug Imipramine (15mg/kg), and St. John's wort extract (250 mg/kg). The antidepressant effect may be related to the presence of the bioactive flavonoids, hyperoside and isoquercitrin, found in PosinolT. These same actives are present in St. John's Wort extract.

PosinolT has a strong safety record and has recently been tested for toxicity. The plant source has a long history of use. In an acute toxicity study, mice given either 2,000 mg (single dose) of PosinolT or 250 mg of PosinolT per kilogram of body weight for two weeks, showed neither abnormality nor body weight gain when compared to the control group. Also, in the case reports study, subjects with depression who took 50 mg/day of PosinolT for periods ranging from 2 weeks to 3.5 years experienced the beneficial effects of this herb without adverse reactions.

Supplementation with PosinolT plays a vital role in creating a positive mental outlook.

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	Depression is a mood disorder that causes one to feel sad or hopeless for an extended period of time. According to the Depression and Bipolar Support Alliance, depression is the most common serious brain disease in the United States, affecting more than 23 million adults each year. Despite advances in the pharmacotherapy of depression, only one third of patients respond favorably to antidepressant drugs. Because of the poor outcomes of treatment with antidepressant medication, patients are increasingly using complementary and alternative medicine. One such alternative is Posinol™. It is made with an extract from the leaves of Apocynum venetum L., a wild plant grown in Asia. Posinol™ contains no less than 4% of the flavonoid glycosides-isoquercitrin and hyperoside. Hyperoside is known to be most efficacious in mental relaxation and reducing blood pressure. It works with the brain's naturally-occurring chemicals called neurotransmitters, including norepinephrine and dopamine. Posinol™ differs from St. John's wort in that it does not contain hyperforin, an active compound that interacts with the metabolism of certain pharmaceuticals. Don't be overwhelmed. Overcome with Posinol™. View Science PosinolT has several case reports indicating that doses of 50 mg/day could help in reducing symptoms of mild to moderate depression. PosinolT shortened the immobility time in an animal model for antidepressant activity at a dose of 15 mg/kg, indicating possible antidepressant activity. This effect was comparable to that of the antidepressant drug Imipramine (15mg/kg), and St. John's wort extract (250 mg/kg). The antidepressant effect may be related to the presence of the bioactive flavonoids, hyperoside and isoquercitrin, found in PosinolT. These same actives are present in St. John's Wort extract. PosinolT has a strong safety record and has recently been tested for toxicity. The plant source has a long history of use. In an acute toxicity study, mice given either 2,000 mg (single dose) of PosinolT or 250 mg of PosinolT per kilogram of body weight for two weeks, showed neither abnormality nor body weight gain when compared to the control group. Also, in the case reports study, subjects with depression who took 50 mg/day of PosinolT for periods ranging from 2 weeks to 3.5 years experienced the beneficial effects of this herb without adverse reactions. Supplementation with PosinolT plays a vital role in creating a positive mental outlook. Hide Science








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